Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis

NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however,...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Haque, Effi, Karim, M. Rezaul, Salam Teeli, Aamir, Śmiech, Magdalena, Leszczynski, Paweł, Winiarczyk, Dawid, Parvanov, Emil D., Atanasov, Atanas G., Taniguchi, Hiroaki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432811/
https://ncbi.nlm.nih.gov/pubmed/32751080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155378
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