Discrimination between G/C Binding Sites by Olivomycin A Is Determined by Kinetics of the Drug-DNA Interaction

Olivomycin A (OA) exerts its cytotoxic potency due to binding to the minor groove of the G/C-rich DNA and interfering with replication and transcription. Screening of the complete set of tetranucleotide G/C sites by electrophoretic mobility gel shift assay (EMSA) revealed that the sites containing c...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Beniaminov, Artemy D., Chashchina, Galina V., Livshits, Mikhail A., Kechko, Olga I., Mitkevich, Vladimir A., Mamaeva, Olga K., Tevyashova, Anna N., Shtil, Alexander A., Shchyolkina, Anna K., Kaluzhny, Dmitry N.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432603/
https://ncbi.nlm.nih.gov/pubmed/32722584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21155299
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