Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand

The indolocarbazole derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) has demonstrated a high potency (at nanomolar to submicromolar concentrations) towards the NCI panel of human tumor cell lines and transplanted tumors. Intercalation into the DNA double helix...

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Detalhes bibliográficos
Main Authors: Kaluzhny, Dmitry N., Shchyolkina, Anna K., Ilyinsky, Nikolay S., Borisova, Olga F., Shtil, Alexander A.
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE-Hindawi Access to Research 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3136114/
https://ncbi.nlm.nih.gov/pubmed/21772991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4061/2011/184735
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