Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes

The 26S proteasome, a self-compartmentalized protease complex, plays a crucial role in protein quality control. Multiple levels of regulatory systems modulate proteasomal activity for substrate hydrolysis. However, the destruction mechanism of mammalian proteasomes is poorly understood. We found tha...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Choi, Won Hoon, Yun, Yejin, Park, Seoyoung, Jeon, Jun Hyoung, Lee, Jeeyoung, Lee, Jung Hoon, Yang, Su-A, Kim, Nak-Kyoon, Jung, Chan Hoon, Kwon, Yong Tae, Han, Dohyun, Lim, Sang Min, Lee, Min Jae
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430983/
https://ncbi.nlm.nih.gov/pubmed/32723828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920327117
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