Cloning and functional complementation of ten Schistosoma mansoni phosphodiesterases expressed in the mammalian host stages

Only a single drug against schistosomiasis is currently available and new drug development is urgently required but very few drug targets have been validated and characterised. However, regulatory systems including cyclic nucleotide metabolism are emerging as primary candidates for drug discovery. H...

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Gepubliceerd in:PLoS Negl Trop Dis
Hoofdauteurs: Munday, Jane C., Kunz, Stefan, Kalejaiye, Titilola D., Siderius, Marco, Schroeder, Susanne, Paape, Daniel, Alghamdi, Ali H., Abbasi, Zainab, Huang, Sheng Xiang, Donachie, Anne-Marie, William, Samia, Sabra, Abdel Nasser, Sterk, Geert Jan, Botros, Sanaa S., Brown, David G., Hoffman, Charles S., Leurs, Rob, de Koning, Harry P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430754/
https://ncbi.nlm.nih.gov/pubmed/32730343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0008447
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