Human GTPBP5 (MTG2) fuels mitoribosome large subunit maturation by facilitating 16S rRNA methylation

Biogenesis of mammalian mitochondrial ribosomes (mitoribosomes) involves several conserved small GTPases. Here, we report that the Obg family protein GTPBP5 or MTG2 is a mitochondrial protein whose absence in a TALEN-induced HEK293T knockout (KO) cell line leads to severely decreased levels of the 5...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Maiti, Priyanka, Antonicka, Hana, Gingras, Anne-Claude, Shoubridge, Eric A, Barrientos, Antoni
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430652/
https://ncbi.nlm.nih.gov/pubmed/32652011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa592
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