Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning

Despite a sizeable body of research, the efficacy of therapeutic cancer vaccines remains limited when applied as sole agents. By using a prime:boost approach involving two viral cancer vaccines, we were able to generate large tumor-specific CD8(+) T-cell responses in a murine model of disseminated p...

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Bibliographische Detailangaben
Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Pol, Jonathan G, Atherton, Matthew J, Stephenson, Kyle B, Bridle, Byram W, Workenhe, Samuel T, Kazdhan, Natasha, McGray, AJ Robert, Wan, Yonghong, Kroemer, Guido, Lichty, Brian D
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Oncolytic and Local Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430484/
https://ncbi.nlm.nih.gov/pubmed/32792361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000981
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