Pathogenic Germline Mutations in DNA Repair Genes in Combination With Cancer Treatment Exposures and Risk of Subsequent Neoplasms Among Long-Term Survivors of Childhood Cancer

PURPOSE: To investigate cancer treatment plus pathogenic germline mutations (PGMs) in DNA repair genes (DRGs) for identification of childhood cancer survivors at increased risk of subsequent neoplasms (SNs). METHODS: Whole-genome sequencing was performed on blood-derived DNA from survivors in the St...

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Vydáno v:J Clin Oncol
Hlavní autoři: Qin, Na, Wang, Zhaoming, Liu, Qi, Song, Nan, Wilson, Carmen L., Ehrhardt, Matthew J., Shelton, Kyla, Easton, John, Mulder, Heather, Kennetz, Dennis, Edmonson, Michael N., Rusch, Michael C., Downing, James R., Hudson, Melissa M., Nichols, Kim E., Zhang, Jinghui, Robison, Leslie L., Yasui, Yutaka
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2020
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ORIGINAL REPORTS
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430217/
https://ncbi.nlm.nih.gov/pubmed/32496904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.19.02760
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