Recombinant thrombomodulin protects against LPS‐induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx

BACKGROUND AND PURPOSE: Disruption of the endothelial glycocalyx is causally related to microvascular endothelial dysfunction, a characteristic of sepsis‐induced acute respiratory distress syndrome (ARDS). Recombinant human thrombomodulin (rhTM) attenuates vascular endothelial injuries, but the unde...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Suzuki, Kodai, Okada, Hideshi, Takemura, Genzou, Takada, Chihiro, Tomita, Hiroyuki, Yano, Hirohisa, Muraki, Isamu, Zaikokuji, Ryogen, Kuroda, Ayumi, Fukuda, Hirotsugu, Nishio, Ayane, Takashima, Shigeo, Suzuki, Akio, Miyazaki, Nagisa, Fukuta, Tetsuya, Yamada, Noriaki, Watanabe, Takatomo, Doi, Tomoaki, Yoshida, Takahiro, Kumada, Keisuke, Ushikoshi, Hiroaki, Yoshida, Shozo, Ogura, Shinji
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2020
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429482/
https://ncbi.nlm.nih.gov/pubmed/32497259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15153
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