Neutrophil Elastase Inhibition Ameliorates Endotoxin-induced Myocardial Injury Accompanying Degradation of Cardiac Capillary Glycocalyx

Myocardial injury in sepsis may be caused by a burst of several inflammatory mediators, leading to vascular endothelial injuries. However, the contribution of neutrophil elastase (NE) to myocardial injury in sepsis is still unknown. We aimed to evaluate whether endotoxemia-induced myocardial injury...

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Detalhes bibliográficos
Publicado no:Shock
Main Authors: Fukuta, Tetsuya, Okada, Hideshi, Takemura, Genzou, Suzuki, Kodai, Takada, Chihiro, Tomita, Hiroyuki, Suzuki, Akio, Oda, Kazumasa, Uchida, Akihiro, Matsuo, Saori, Fukuda, Hirotsugu, Yano, Hirohisa, Muraki, Isamu, Zaikokuji, Ryogen, Kuroda, Ayumi, Nishio, Ayane, Sampei, So, Miyazaki, Nagisa, Hotta, Yasuaki, Yamada, Noriaki, Watanabe, Takatomo, Morishita, Kentaro, Doi, Tomoaki, Yoshida, Takahiro, Ushikoshi, Hiroaki, Yoshida, Shozo, Maekawa, Yoichi, Ogura, Shinji
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
Assuntos:
Basic Science Aspects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7748054/
https://ncbi.nlm.nih.gov/pubmed/31764619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001482
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