Anti‐ORAI1 antibody DS‐2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T‐cell and mast cell activation

ORAI1 constitutes the pore‐forming subunit of the calcium release‐activated calcium (CRAC) channel, which is responsible for store‐operated calcium entry into lymphocytes. It is known that ORAI1 is essential for the activation of T cells and mast cells and is considered to be a potent therapeutic ta...

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Detalhes bibliográficos
Publicado no:FASEB Bioadv
Main Authors: Aki, Anri, Tanaka, Kento, Nagaoka, Nobumi, Kimura, Takako, Baba, Daichi, Onodera, Yoshikuni, Wada, Teiji, Maeda, Hiroaki, Nakanishi, Toshiyuki, Agatsuma, Toshinori, Komai, Tomoaki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429349/
https://ncbi.nlm.nih.gov/pubmed/32821879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fba.2020-00008
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