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PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches
INTRODUCTION: The human liver is the center for drug metabolism and detoxification and is, therefore, constantly exposed to toxic chemicals. The loss of liver function as a result of this exposure is referred to as drug-induced liver injury (DILI). The pregnane X receptor (PXR) is the primary regula...
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| 出版年: | Expert Opin Drug Metab Toxicol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7429329/ https://ncbi.nlm.nih.gov/pubmed/32500752 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/17425255.2020.1779701 |
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