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The three dimensions of somatic evolution: Integrating the role of genetic damage, life‐history traits, and aging in carcinogenesis

Tumors result from genetic and epigenetic alterations that change cellular survival and differentiation probabilities, promoting clonal dominance. Subsequent genetic and selection processes in tumors allow cells to lose their tissue fidelity and migrate to other parts of the body, turning tumors int...

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Detalles Bibliográficos
Publicado en:Evol Appl
Main Authors: Rozhok, Andrii I., DeGregori, James
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428813/
https://ncbi.nlm.nih.gov/pubmed/32821273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12947
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