Interleukin‐22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription‐3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury

BACKGROUND: Interleukin (IL)‐22, a member of the IL‐10 cytokine family, is the only known cytokine that is secreted by immune cells but does not target immune cells; it mainly targets epithelial cells. In this study, we aimed to determine whether IL‐22 administration could activate the myocardial ST...

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Veröffentlicht in:J Am Heart Assoc
Hauptverfasser: Takahashi, Jinya, Yamamoto, Mai, Yasukawa, Hideo, Nohara, Shoichiro, Nagata, Takanobu, Shimozono, Koutatsu, Yanai, Toshiyuki, Sasaki, Tomoko, Okabe, Kota, Shibata, Tatsuhiro, Mawatari, Kazutoshi, Kakuma, Tatsuyuki, Aoki, Hiroki, Fukumoto, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428538/
https://ncbi.nlm.nih.gov/pubmed/32301368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.014814
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