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Prostaglandin E Receptor EP4 expression, survival and pattern of recurrence in locally advanced NSCLC

BACKGROUND: Elevated COX-2 expression has been correlated with inferior outcome in NSCLC. COX-2 catalyzes the transformation of arachidonate to PGE2. We and others have demonstrated that PGE2 induces proliferation and metastatic spread and immunosuppression through the G protein-coupled EP4 receptor...

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Bibliografski detalji
Izdano u:Lung Cancer
Glavni autori: Bhooshan, Neha, Staats, Paul N., Fulton, Amy M., Feliciano, Josephine L., Edelman, Martin J.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428069/
https://ncbi.nlm.nih.gov/pubmed/27794413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2016.09.011
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