Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance

The DNA polymerase Polκ plays a key role in translesion synthesis, an error-prone replication mechanism. Polκ is overexpressed in various tumor types. Here, we found that melanoma and lung and breast cancer cells experiencing stress from oncogene inhibition upregulated the expression of Polκ and shi...

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Vydáno v:Sci Signal
Hlavní autoři: Temprine, Kelsey, Campbell, Nathaniel R., Huang, Richard, Langdon, Erin M, Simon-Vermot, Theresa, Mehta, Krisha, Clapp, Averill, Chipman, Mollie, White, Richard M
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7428051/
https://ncbi.nlm.nih.gov/pubmed/32345725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau1453
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