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Regulation of the error-prone DNA polymerase Polκ by oncogenic signaling and its contribution to drug resistance
The DNA polymerase Polκ plays a key role in translesion synthesis, an error-prone replication mechanism. Polκ is overexpressed in various tumor types. Here, we found that melanoma and lung and breast cancer cells experiencing stress from oncogene inhibition upregulated the expression of Polκ and shi...
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| Publicado no: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7428051/ https://ncbi.nlm.nih.gov/pubmed/32345725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau1453 |
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