The Human Integrator Complex Facilitates Transcriptional Elongation by Endonucleolytic Cleavage of Nascent Transcripts

Transcription by RNA polymerase II (RNAPII) is pervasive in the human genome. However, the mechanisms controlling transcription at promoters and enhancers remain enigmatic. Here, we demonstrate that Integrator subunit 11 (INTS11), the catalytic subunit of the Integrator complex, regulates transcript...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Beckedorff, Felipe, Blumenthal, Ezra, daSilva, Lucas Ferreira, Aoi, Yuki, Cingaram, Pradeep Reddy, Yue, Jingyin, Zhang, Anda, Dokaneheifard, Sadat, Valencia, Monica Guiselle, Gaidosh, Gabriel, Shilatifard, Ali, Shiekhattar, Ramin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427568/
https://ncbi.nlm.nih.gov/pubmed/32697989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107917
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