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Nascent Transcript Folding Plays a Major Role in Determining RNA Polymerase Elongation Rates
Transcription elongation rates influence RNA processing, but sequence-specific regulation is poorly understood. We addressed this in vivo, analyzing RNAPI in S. cerevisiae. Mapping RNAPI by Miller chromatin spreads or UV crosslinking revealed 5′ enrichment and strikingly uneven local polymerase occu...
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| Publicat a: | Mol Cell |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cell Press
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7427326/ https://ncbi.nlm.nih.gov/pubmed/32585128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.06.002 |
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