Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

New therapeutics are urgently needed to inhibit SARS-CoV-2, the virus responsible for the ongoing Covid-19 pandemic. Nsp15, a uridine-specific endoribonuclease found in all coronaviruses, processes viral RNA to evade detection by RNA-activated host defense systems, making it a promising drug target....

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Pillon, Monica C., Frazier, Meredith N., Dillard, Lucas B., Williams, Jason G., Kocaman, Seda, Krahn, Juno M., Perera, Lalith, Hayne, Cassandra K., Gordon, Jacob, Stewart, Zachary D., Sobhany, Mack, Deterding, Leesa J., Hsu, Allen L., Dandey, Venkata P., Borgnia, Mario J., Stanley, Robin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7427136/
https://ncbi.nlm.nih.gov/pubmed/32803198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.08.11.244863
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