Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the enzyme recognizes and processes RNA remains poorly u...

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Publicado no:Nat Commun
Main Authors: Pillon, Monica C., Frazier, Meredith N., Dillard, Lucas B., Williams, Jason G., Kocaman, Seda, Krahn, Juno M., Perera, Lalith, Hayne, Cassandra K., Gordon, Jacob, Stewart, Zachary D., Sobhany, Mack, Deterding, Leesa J., Hsu, Allen L., Dandey, Venkata P., Borgnia, Mario J., Stanley, Robin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7840905/
https://ncbi.nlm.nih.gov/pubmed/33504779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20608-z
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