ABHD11 maintains 2-oxoglutarate metabolism by preserving functional lipoylation of the 2-oxoglutarate dehydrogenase complex

2-oxoglutarate (2-OG or α-ketoglutarate) relates mitochondrial metabolism to cell function by modulating the activity of 2-OG dependent dioxygenases involved in the hypoxia response and DNA/histone modifications. However, metabolic pathways that regulate these oxygen and 2-OG sensitive enzymes remai...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bailey, Peter S. J., Ortmann, Brian M., Martinelli, Anthony W., Houghton, Jack W., Costa, Ana S. H., Burr, Stephen P., Antrobus, Robin, Frezza, Christian, Nathan, James A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426941/
https://ncbi.nlm.nih.gov/pubmed/32792488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17862-6
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