FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

Regulation of the programming of tumour-associated macrophages (TAMs) controls tumour growth and anti-tumour immunity. We examined the role of FGF2 in that regulation. Tumours in mice genetically deficient in low-molecular weight FGF2 (FGF2(LMW)) regress dependent on T cells. Yet, TAMS not T cells e...

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Publicat a:Nat Commun
Autors principals: Im, Jae Hong, Buzzelli, Jon N., Jones, Keaton, Franchini, Fanny, Gordon-Weeks, Alex, Markelc, Bostjan, Chen, Jianzhou, Kim, Jin, Cao, Yunhong, Muschel, Ruth J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426415/
https://ncbi.nlm.nih.gov/pubmed/32792542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17914-x
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