A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

Telomeric G-quadruplexes (G4) were long believed to form a protective structure at telomeres, preventing their extension by the ribonucleoprotein telomerase. Contrary to this belief, we have previously demonstrated that parallel-stranded conformations of telomeric G4 can be extended by human and cil...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Paudel, Bishnu P, Moye, Aaron Lavel, Abou Assi, Hala, El-Khoury, Roberto, Cohen, Scott B, Holien, Jessica K, Birrento, Monica L, Samosorn, Siritron, Intharapichai, Kamthorn, Tomlinson, Christopher G, Teulade-Fichou, Marie-Paule, González, Carlos, Beck, Jennifer L, Damha, Masad J, van Oijen, Antoine M, Bryan, Tracy M
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
Soggetti:
Biochemistry and Chemical Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426096/
https://ncbi.nlm.nih.gov/pubmed/32723475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56428
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