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Structure and dynamics of a nanodisc by integrating NMR, SAXS and SANS experiments with molecular dynamics simulations

Nanodiscs are membrane mimetics that consist of a protein belt surrounding a lipid bilayer, and are broadly used for characterization of membrane proteins. Here, we investigate the structure, dynamics and biophysical properties of two small nanodiscs, MSP1D1ΔH5 and ΔH4H5. We combine our SAXS and SAN...

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Dettagli Bibliografici
Pubblicato in:eLife
Autori principali: Bengtsen, Tone, Holm, Viktor L, Kjølbye, Lisbeth Ravnkilde, Midtgaard, Søren R, Johansen, Nicolai Tidemand, Tesei, Giulio, Bottaro, Sandro, Schiøtt, Birgit, Arleth, Lise, Lindorff-Larsen, Kresten
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7426092/
https://ncbi.nlm.nih.gov/pubmed/32729831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56518
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