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Tumor Suppressor miR-22 Determines p53-Dependent Cellular Fate through Post-transcriptional Regulation of p21

Selective activation of p53 target genes in response to various cellular stresses is a critical step in determining the ability to induce cell-cycle arrest or apoptosis. Here we report the identification of the microRNA miR-22 as a p53 target gene that selectively determines the induction of p53-dep...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Tsuchiya, Naoto, Izumiya, Masashi, Ogata-Kawata, Hiroko, Okamoto, Koji, Fujiwara, Yuko, Nakai, Makiko, Okabe, Atsushi, Schetter, Aaron J., Bowman, Elise D., Midorikawa, Yutaka, Sugiyama, Yasuyuki, Aburatani, Hiroyuki, Harris, Curtis C., Nakagama, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425979/
https://ncbi.nlm.nih.gov/pubmed/21565979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2475
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