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miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver

Liver metastasis is a major lethal complication associated with colon cancer, and post-intravasation steps of the metastasis are important for its clinical intervention. In order to identify inhibitory microRNAs (miRNAs) for these steps, we performed ‘dropout' screens of a miRNA library in a mo...

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Detalhes bibliográficos
Main Authors: Okamoto, Koji, Ishiguro, Tatsuya, Midorikawa, Yutaka, Ohata, Hirokazu, Izumiya, Masashi, Tsuchiya, Naoto, Sato, Ai, Sakai, Hiroaki, Nakagama, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321205/
https://ncbi.nlm.nih.gov/pubmed/22373578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.25
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