Crosstalk between EP2 and PPARα Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs

PURPOSE: Cyclic adenosine monophosphate (cAMP) and peroxisome proliferator-activated receptor alpha (PPARα) levels mediate extracellular matrix (ECM) changes by altering the levels of hypoxia-inducible factor 1-alpha (HIF-1α) in various tissues. We aimed to determine, in the sclera of guinea pigs, w...

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Gepubliceerd in:Invest Ophthalmol Vis Sci
Hoofdauteurs: Srinivasalu, Nethrajeith, Zhang, Sen, Xu, Renchang, Reinach, Peter Sol, Su, Yongchao, Zhu, Yun, Qu, Jia, Zhou, Xiangtian
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Association for Research in Vision and Ophthalmology 2020
Onderwerpen:
Biochemistry and Molecular Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425689/
https://ncbi.nlm.nih.gov/pubmed/32725213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.8.44
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