Alterations in Driver Genes are Predictive of Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma

BACKGROUND: KRAS, TP53, CDKN2A and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). We aimed to determine if the mutational status of driver genes, and those involved in DNA repair pathways, are associated with clinical outcomes in individuals who undergo resection. MET...

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Detalhes bibliográficos
Publicado no:Cancer
Main Authors: McIntyre, Caitlin A., Lawrence, Sharon A., Richards, Allison L., Chou, Joanne F., Wong, Winston, Capanu, Marinela, Berger, Michael F., Donoghue, Mark T.A., Yu, Kenneth H., Varghese, Anna M., Kelsen, David P., Park, Wungki, Balachandran, Vinod P., Kingham, T. Peter, D’Angelica, Michael I., Drebin, Jeffrey A., Jarnagin, William R., Iacobuzio-Donahue, Christine A., Allen, Peter J., O’Reilly, Eileen M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424538/
https://ncbi.nlm.nih.gov/pubmed/32573775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.33038
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