Alterations in Driver Genes are Predictive of Survival in Patients with Resected Pancreatic Ductal Adenocarcinoma

BACKGROUND: KRAS, TP53, CDKN2A and SMAD4 are established driver genes in pancreatic ductal adenocarcinoma (PDAC). We aimed to determine if the mutational status of driver genes, and those involved in DNA repair pathways, are associated with clinical outcomes in individuals who undergo resection. MET...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer
Auteurs principaux: McIntyre, Caitlin A., Lawrence, Sharon A., Richards, Allison L., Chou, Joanne F., Wong, Winston, Capanu, Marinela, Berger, Michael F., Donoghue, Mark T.A., Yu, Kenneth H., Varghese, Anna M., Kelsen, David P., Park, Wungki, Balachandran, Vinod P., Kingham, T. Peter, D’Angelica, Michael I., Drebin, Jeffrey A., Jarnagin, William R., Iacobuzio-Donahue, Christine A., Allen, Peter J., O’Reilly, Eileen M.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424538/
https://ncbi.nlm.nih.gov/pubmed/32573775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.33038
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