Enzymatically synthesized 2′-fluoro-modified Dicer-substrate siRNA swarms against herpes simplex virus demonstrate enhanced antiviral efficacy and low cytotoxicity

Chemical modifications of small interfering (si)RNAs are used to enhance their stability and potency, and to reduce possible off-target effects, including immunogenicity. We have earlier introduced highly effective antiviral siRNA swarms against herpes simplex virus (HSV), targeting 653 bp of the es...

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Foilsithe in:Antiviral Res
Main Authors: Levanova, Alesia A., Kalke, Kiira M., Lund, Liisa M., Sipari, Nina, Sadeghi, Mohammadreza, Nyman, Marie C., Paavilainen, Henrik, Hukkanen, Veijo, Poranen, Minna M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Published by Elsevier B.V. 2020
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7424292/
https://ncbi.nlm.nih.gov/pubmed/32798603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2020.104916
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