Herpes Simplex Virus Type 1 Clinical Isolates Respond to UL29-Targeted siRNA Swarm Treatment Independent of Their Acyclovir Sensitivity

Acyclovir is the drug of choice for the treatment of herpes simplex virus (HSV) infections. Acyclovir-resistant HSV strains may emerge, especially during long-term drug use, and subsequently cause difficult-to-treat exacerbations. Previously, we set up a novel treatment approach, based on enzymatica...

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Foilsithe in:Viruses
Main Authors: Kalke, Kiira, Lehtinen, Jenni, Gnjatovic, Jelena, Lund, Liisa M., Nyman, Marie C., Paavilainen, Henrik, Orpana, Julius, Lasanen, Tuomas, Frejborg, Fanny, Levanova, Alesia A., Vuorinen, Tytti, Poranen, Minna M., Hukkanen, Veijo
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2020
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7764767/
https://ncbi.nlm.nih.gov/pubmed/33322225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12121434
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