Controversy of physiological vs. pharmacological effects of BMP signaling: Constitutive activation of BMP type IA receptor-dependent signaling in osteoblast lineage enhances bone formation and resorption, not affecting net bone mass

Bone morphogenetic proteins (BMPs) were first described over 50 years ago as potent inducers of ectopic bone formation when administrated subcutaneously. Preclinical studies have extensively examined the osteoinductive properties of BMPs in vitro and new bone formation in vivo. BMPs (BMP-2, BMP-7) h...

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Detalhes bibliográficos
Publicado no:Bone
Main Authors: Kamiya, Nobuhiro, Atsawasuwan, Phimon, Joiner, Danese M., Waldorff, Erik I., Goldstein, Steve, Yamauchi, Mitsuo, Mishina, Yuji
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7423725/
https://ncbi.nlm.nih.gov/pubmed/32603910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2020.115513
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