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Lamivudine Inhibits Alu RNA-induced Retinal Pigment Epithelium Degeneration via Anti-inflammatory and Anti-senescence Activities
PURPOSE: Accumulation of the long noncoding Alu element RNA activates the NLRP3 inflammasome and leads to retinal pigment epithelium (RPE) cell death, a key event in the pathogenesis of geographic atrophy during late-stage age-related macular degeneration. Lamivudine (3TC) is a nucleoside analog rev...
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| Pubblicato in: | Transl Vis Sci Technol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Association for Research in Vision and Ophthalmology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7422901/ https://ncbi.nlm.nih.gov/pubmed/32855848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.9.8.1 |
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