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Pharmacogenetic aspects of methotrexate in a cohort of Colombian patients with rheumatoid arthritis

Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug for the treatment of rheumatoid arthritis (RA). However, over time, ~40% of patients may experience therapeutic failure or drug toxicity. The genetic variability of the enzymes involved in the MTX metabolic pathway see...

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Publicado en:Biomed Rep
Autores principales: Londono, John, Saldarriaga, Eugenia-Lucia, Rueda, Juan C., Giraldo-Bustos, Rodrigo, Angarita, Jose-Ignacio, Restrepo, Luisa, Ballesteros-Muñoz, Jesus, González, Camilo, Ospina, Maria J., Arias-Correal, Sofia, Reyes-Martinez, Viviana, Bernalmacias, Santiago, Villota-Eraso, Catalina, Santos-Moreno, Pedro, Martinez-Rodriguez, Nancy, Santos, Ana M.
Formato: Artigo
Lenguaje:Inglês
Publicado: D.A. Spandidos 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418498/
https://ncbi.nlm.nih.gov/pubmed/32793348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/br.2020.1341
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