Amyloid-β Causes Mitochondrial Dysfunction via a Ca(2+)-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells

Cerebrovascular pathology is pervasive in Alzheimer’s disease (AD), yet it is unknown whether cerebrovascular dysfunction contributes to the progression or etiology of AD. In human subjects and in animal models of AD, cerebral hypoperfusion and hypometabolism are reported to manifest during the earl...

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Vydáno v:J Alzheimers Dis
Hlavní autoři: Quintana, Dominic D., Garcia, Jorge A., Anantula, Yamini, Rellick, Stephanie L., Engler-Chiurazzi, Elizabeth B., Sarkar, Saumyendra N., Brown, Candice M., Simpkins, James W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418488/
https://ncbi.nlm.nih.gov/pubmed/32250296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190964
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