Amyloid-β Causes Mitochondrial Dysfunction via a Ca(2+)-Driven Upregulation of Oxidative Phosphorylation and Superoxide Production in Cerebrovascular Endothelial Cells

Cerebrovascular pathology is pervasive in Alzheimer’s disease (AD), yet it is unknown whether cerebrovascular dysfunction contributes to the progression or etiology of AD. In human subjects and in animal models of AD, cerebral hypoperfusion and hypometabolism are reported to manifest during the earl...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Quintana, Dominic D., Garcia, Jorge A., Anantula, Yamini, Rellick, Stephanie L., Engler-Chiurazzi, Elizabeth B., Sarkar, Saumyendra N., Brown, Candice M., Simpkins, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418488/
https://ncbi.nlm.nih.gov/pubmed/32250296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-190964
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