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An Efficient Method for the Synthesis of Peptide Aldehyde Libraries Employed in the Discovery of Reversible SARS Coronavirus Main Protease (SARS‐CoV M(pro)) Inhibitors
A method for the parallel solid‐phase synthesis of peptide aldehydes has been developed. Protected amino acid aldehydes obtained by the racemization‐free oxidation of amino alcohols with Dess–Martin periodinane were immobilized on threonyl resins as oxazolidines. Following Boc protection of the ring...
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| Pubblicato in: | Chembiochem |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
WILEY‐VCH Verlag
2006
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7417790/ https://ncbi.nlm.nih.gov/pubmed/16688706 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200500533 |
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