Cost-effectiveness of CYP2C19-guided antiplatelet therapy in patients with acute coronary syndrome and percutaneous coronary intervention informed by real-world data

Current guidelines recommend dual antiplatelet therapy (DAPT) consisting of aspirin and a P2Y12 inhibitors following percutaneous coronary intervention (PCI). CYP2C19 genotype can guide DAPT selection, prescribing ticagrelor or prasugrel for loss-of-function (LOF) allele carriers (genotype-guided es...

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Udgivet i:Pharmacogenomics J
Main Authors: Limdi, Nita A., Cavallari, Larisa H., Lee, Craig R., Hillegass, William B., Holmes, Ann M., Skaar, Todd C., Pisu, Maria, Dillon, Chrisly, Beitelshees, Amber L., Empey, Philip E., Duarte, Julio D., Diaby, Vakaramoko, Gong, Yan, Johnson, Julie A., Graves, John, Garbett, Shawn, Zhou, Zilu, Peterson, Josh F.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417282/
https://ncbi.nlm.nih.gov/pubmed/32042096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41397-020-0162-5
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