Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

The use of cannabis is rapidly expanding worldwide. Thus, innovative studies aimed to identify, understand and potentially reduce cannabis-evoked harms are warranted. Here, we found that Δ(9)-tetrahydrocannabinol, the psychoactive ingredient of cannabis, disrupts autophagy selectively in the striatu...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Blázquez, Cristina, Ruiz-Calvo, Andrea, Bajo-Grañeras, Raquel, Baufreton, Jérôme M, Resel, Eva, Varilh, Marjorie, Pagano Zottola, Antonio C, Mariani, Yamuna, Cannich, Astrid, Rodríguez-Navarro, José A, Marsicano, Giovanni, Galve-Roperh, Ismael, Bellocchio, Luigi, Guzmán, Manuel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7417168/
https://ncbi.nlm.nih.gov/pubmed/32773031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56811
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