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Phenotypic analysis of mutations at residue 146 provides insights into the relationship between NS5A hyperphosphorylation and hepatitis C virus genome replication

The hepatitis C virus genotype 2a isolate, JFH-1, exhibits much more efficient genome replication than other isolates. Although basic replication mechanisms must be conserved, this raises the question of whether the regulation of replication might exhibit isolate- and/or genotype-specific characteri...

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Bibliographic Details
Published in:J Gen Virol
Main Authors: Goonawardane, Niluka, Yin, Chunhong, Harris, Mark
Format: Artigo
Language:Inglês
Published: Microbiology Society 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416608/
https://ncbi.nlm.nih.gov/pubmed/31821131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.001366
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