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AML chemoresistance: The role of mutant TP53 subclonal expansion and therapy strategy

Acute myeloid leukemia (AML) is a heterogeneous clonal disease characterized by the proliferation and accumulation of myeloid blast cells in the bone marrow which eventually leads to hematopoietic failure. Chemoresistance presents as a major burden for therapy of AML patients. TP53 is the most impor...

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Detalhes bibliográficos
Publicado no:Exp Hematol
Main Authors: Yan, Bowen, Claxton, David, Huang, Suming, Qiu, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416446/
https://ncbi.nlm.nih.gov/pubmed/32569759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2020.06.003
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