Combination therapy with radiation and PARP inhibition enhances responsiveness to anti-PD-1 therapy in colorectal tumor models.

PURPOSE: The majority of colorectal cancers are resistant to cancer immune-checkpoint inhibitors. Ionizing radiation (IR) and several radiosensitizers, including PARP inhibitors, can enhance responsiveness to immune checkpoint inhibitors by potentially complementary mechanisms of action. We assessed...

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Udgivet i:Int J Radiat Oncol Biol Phys
Main Authors: Seyedin, Steven N., Hasibuzzaman, MM, Pham, Vivan, Petronek, Michael S., Callaghan, Cameron, Kalen, Amanda L., Mapuskar, Kranti A, Mott, Sarah L., Spitz, Douglas R., Allen, Bryan G., Caster, Joseph M.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416439/
https://ncbi.nlm.nih.gov/pubmed/32036006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2020.01.030
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