Helicobacter pylori infection downregulates the DNA glycosylase NEIL2, resulting in increased genome damage and inflammation in gastric epithelial cells

Infection with the Gram-negative, microaerophilic bacterium Helicobacter pylori induces an inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to gastric cancer (GC). However, the underlying pathogenic mechanism is largely unclear. Here, we report that the suppre...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sayed, Ibrahim M., Sahan, Ayse Z., Venkova, Tatiana, Chakraborty, Anirban, Mukhopadhyay, Dibyabrata, Bimczok, Diane, Beswick, Ellen J., Reyes, Victor E., Pinchuk, Irina, Sahoo, Debashis, Ghosh, Pradipta, Hazra, Tapas K., Das, Soumita
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415988/
https://ncbi.nlm.nih.gov/pubmed/32518160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009981
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