The RAS-interacting chaperone UNC119 drives the RASSF6–MDM2–p53 axis and antagonizes RAS-mediated malignant transformation

The gene encoding the proto-oncogene GTPase RAS is frequently mutated in human cancers. Mutated RAS proteins trigger antiapoptotic and cell-proliferative signals and lead to oncogenesis. However, RAS also induces apoptosis and senescence, which may contribute to the eradication of cells with RAS mut...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Shimizu, Takanobu, Nakamura, Takeshi, Inaba, Hironori, Iwasa, Hiroaki, Maruyama, Junichi, Arimoto-Matsuzaki, Kyoko, Nakata, Takao, Nishina, Hiroshi, Hata, Yutaka
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2020
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415979/
https://ncbi.nlm.nih.gov/pubmed/32554467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012649
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