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The RAS-interacting chaperone UNC119 drives the RASSF6–MDM2–p53 axis and antagonizes RAS-mediated malignant transformation
The gene encoding the proto-oncogene GTPase RAS is frequently mutated in human cancers. Mutated RAS proteins trigger antiapoptotic and cell-proliferative signals and lead to oncogenesis. However, RAS also induces apoptosis and senescence, which may contribute to the eradication of cells with RAS mut...
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| Опубликовано в: : | J Biol Chem |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7415979/ https://ncbi.nlm.nih.gov/pubmed/32554467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012649 |
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