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Mechanistic insights into heme-mediated transcriptional regulation via a bacterial manganese-binding iron regulator, iron response regulator (Irr)

The transcription factor iron response regulator (Irr) is a key regulator of iron homeostasis in the nitrogen-fixating bacterium Bradyrhizobium japonicum. Irr acts by binding to target genes, including the iron control element (ICE), and is degraded in response to heme binding. Here, we examined thi...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Nam, Dayeon, Matsumoto, Yuki, Uchida, Takeshi, O'Brian, Mark R., Ishimori, Koichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415966/
https://ncbi.nlm.nih.gov/pubmed/32554810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011855
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