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The functional role of the αM4 transmembrane helix in the muscle nicotinic acetylcholine receptor probed through mutagenesis and coevolutionary analyses

The activity of the muscle-type Torpedo nicotinic acetylcholine receptor (nAChR) is highly sensitive to lipids, but the underlying mechanisms remain poorly understood. The nAChR transmembrane α-helix, M4, is positioned at the perimeter of each subunit in direct contact with lipids and likely plays a...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Thompson, Mackenzie J., Domville, Jaimee A., Baenziger, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415963/
https://ncbi.nlm.nih.gov/pubmed/32527728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013751
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