Signaling Between TRPV1/TRPV4 and Intracellular Hydrostatic Pressure in the Mouse Lens

PURPOSE: The lens uses feedback to maintain zero pressure in its surface cells. Positive pressures are detected by transient receptor potential vanilloid (TRPV4), which initiates a cascade that reduces surface cell osmolarity. The first step is opening of gap junction hemichannels. One purpose of th...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Delamere, Nicholas A., Shahidullah, Mohammad, Mathias, Richard T., Gao, Junyuan, Sun, Xiuron, Sellitto, Caterina, White, Thomas W.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2020
Fag:
Lens
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415899/
https://ncbi.nlm.nih.gov/pubmed/32598448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.6.58
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