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Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport.

Most organs use fatty acids (FAs) as a key nutrient, but little is known of how blood-borne FAs traverse the endothelium to reach underlying tissues. We conducted a small-molecule screen and identified niclosamide as a suppressor of endothelial FA uptake and transport. Structure/activity relationshi...

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Détails bibliographiques
Publié dans:Cell Metab
Auteurs principaux: Ibrahim, Ayon, Yucel, Nora, Kim, Boa, Arany, Zoltan
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415739/
https://ncbi.nlm.nih.gov/pubmed/32521232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2020.05.018
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