Metabolic reprograming via deletion of CISH in human iPSC-derived NK cells promotes in vivo persistence and enhances anti-tumor activity

Cytokine-inducible SH2-containing protein (CIS, encoded by the gene CISH) is a key negative regulator of IL-15 signaling in natural killer (NK) cells. Here, we developed human CISH-knockout (CISH(−/−)) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform. CISH(−/−)...

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Publicado no:Cell Stem Cell
Main Authors: Zhu, Huang, Blum, Robert H., Bernareggi, Davide, Ask, Eivind Heggernes, Wu, Zhengming, Hoel, Hanna Julie, Meng, Zhipeng, Wu, Chengsheng, Guan, Kun-Liang, Malmberg, Karl-Johan, Kaufman, Dan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415618/
https://ncbi.nlm.nih.gov/pubmed/32531207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2020.05.008
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