The NSD2 p.E1099K Mutation is Enriched at Relapse and Confers Drug Resistance in a Cell Context Dependent Manner in Pediatric Acute Lymphoblastic Leukemia

The NSD2 p.E1099K (EK) mutation is observed in 10% of acute lymphoblastic leukemia (ALL) samples with enrichment at relapse indicating a role in clonal evolution and drug resistance. To discover mechanisms that mediate clonal expansion, we engineered B-ALL cell lines (Reh, 697) to overexpress wildty...

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Publicado no:Mol Cancer Res
Main Authors: Pierro, Joanna, Saliba, Jason, Narang, Sonali, Sethia, Gunjan, Fleur-Lominy, Shella Saint, Chowdhury, Ashfiyah, Qualls, Anita, Fay, Hannah, Kilberg, Harrison L., Moriyama, Takaya, Fuller, Tori J., Teachey, David T., Schmiegelow, Kjeld, Yang, Jun J., Loh, Mignon L., Brown, Patrick A., Zhang, Jinghui, Ma, Xiaotu, Tsirigos, Aristotelis, Evensen, Nikki A., Carroll, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415532/
https://ncbi.nlm.nih.gov/pubmed/32332049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-20-0092
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