Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling

Background: This study assessed the expression of Jagged2 in human bladder cancer (BC) tested the hypothesis that melatonin (Mel) inhibited the tumorigenesis of BC cells mainly through downregulating the Notch/Jagged2 and PI3K/AKT/mTOR/MMPs((2&9)) signaling pathways. Methods and Results: Tissue...

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Vydáno v:Int J Biol Sci
Hlavní autoři: Chen, Yen-Ta, Huang, Chi-Ruei, Chang, Chia-Lo, Chiang, John Y., Luo, Chi-Wen, Chen, Hong-Hwa, Yip, Hon-Kan
Médium: Artigo
Jazyk:Inglês
Vydáno: Ivyspring International Publisher 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415428/
https://ncbi.nlm.nih.gov/pubmed/32792862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.48358
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